Last update Feb. 27, 2023

Probenecid

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It increases renal excretion of Uric acid and decreases elimination of many drug by the kidneys, among them beta-lactam antibiotics, with augmented plasma levels and effectiveness. It is used to treat gout and hyperuricemia. Oral administration twice a day.

Excretion into breast milk is clinically non-significant, with no problems observed that could be attributed to Probenecid among breastfed infants from treated mothers (Ilett 2006). Reportedly, one case of self-limited diarrhea occurred in a child whose mother was taking cephalosporins together with Probenecid.

Alternatives

We do not have alternatives for Probenecid since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Probenecid in other languages or writings:

Group

Probenecid belongs to this group or family:

Tradenames

Main tradenames from several countries containing Probenecid in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 285 daltons
Protein Binding 85 - 95 %
pKa 3.53 -
Tmax 3 - 4 hours
8.5 (6 - 12) hours
M/P ratio 0.03 -
Theoretical Dose 0.15 mg/Kg/d
Relative Dose 0.7 %

References

  1. Ilett KF, Hackett LP, Ingle B, Bretz PJ. Transfer of probenecid and cephalexin into breast milk. Ann Pharmacother. 2006 Abstract
  2. Emanuelsson BM, Beermann B, Paalzow LK. Non-linear elimination and protein binding of probenecid. Eur J Clin Pharmacol. 1987 Abstract
  3. Selen A, Amidon GL, Welling PG. Pharmacokinetics of probenecid following oral doses to human volunteers. J Pharm Sci. 1982 Abstract

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