Last update Jan. 30, 2022

Lumefantrine

Compatible

Safe substance and/or breastfeeding is the best option.

This dichlorobenzylidine derivative is used in combination with artemether in the treatment of uncomplicated plasmodium falciparum malaria. Oral administration.

It is excreted in human milk in small amounts. (Jain 2015)

Its use is authorized in babies weighing at least 5 kg, so it is unlikely that the small amount that passes through the mothers’ milk could affect the infant.

Various medical societies and expert consensus consider the use of this medication safe during breastfeeding (WHO 2010), especially if the infants are not premature or newborn and weigh more than 5 kg. (CDC 2019, Saito 2018, Adjei 2009)


See below the information of this related product:

Alternatives

  • Chloroquine (Safe substance and/or breastfeeding is the best option.)
  • Mefloquine Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Quinine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Lumefantrine is also known as


Lumefantrine in other languages or writings:

Group

Lumefantrine belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Molecular weight 529 daltons
Protein Binding 100 %
pKa 14.1 -
Tmax 8 - 10 hours
T½ 72 - 96 hours
M/P ratio 1.3 -
Theoretical Dose 3.9 mg/Kg/d
Ped.Relat.Dose 10 %

References

  1. CDC. Centers for Disease Control and Prevention. Tan K, Arguin PM. Chapter 4. Travel-Related Infectious Diseases. Malaria. CDC Health Information for International Travel. 2019 Full text (link to original source)
  2. Saito M, Gilder ME, McGready R, Nosten F. Antimalarial drugs for treating and preventing malaria in pregnant and lactating women. Expert Opin Drug Saf. 2018 Nov;17(11):1129-1144. Abstract Full text (link to original source) Full text (in our servers)
  3. Jain JP, Ganesan S, Lefevre G, Sunkara G. Estimating of the amount of artemether and lumefantrine excreted through breast milk. Abstracts of the 9th European Congress on Tropical Medicine and International Health. Poster Session 1-035. Trop Med Int Health. 2015;20 (Suppl. S1):184-5. Abstract. Full text (link to original source) Full text (in our servers)
  4. WHO. Guidelines for the treatment of malaria. 2nd ed. Geneva: WHO, 2010 2nd ed. Geneva: WHO, 2010 Full text (link to original source) Full text (in our servers)
  5. Adjei GO, Goka BQ, Binka F, Kurtzhals JA. Artemether-lumefantrine: an oral antimalarial for uncomplicated malaria in children. Expert Rev Anti Infect Ther. 2009 Aug;7(6):669-81. Abstract

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