Last update Oct. 15, 2016

Loracarbef

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Second-generation cephalosporin for oral administration with a chemical structure similar to cefaclor.

At latest update no published data on excretion into breast milk were found.

Cephalosporins for which data are available have shown to be excreted into milk in non-significant amount from a therapeutic point of view without reported complications in infants related to them.
Cephalosporins are widely used in the Pediatric practice with a high tolerance, even in the neonatal period, so it is very unlikely that such small amounts present in the milk may be a cause of problems to the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Loracarbef since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Loracarbef in other languages or writings:

Group

Loracarbef belongs to this group or family:

Tradenames

Main tradenames from several countries containing Loracarbef in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 368 daltons
Protein Binding 25 %
VD 0.27 - 0.38 l/Kg
Tmax 1.2 hours
T½ 1 hours

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract

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