Last update Sept. 1, 2022

Cefaclor

Compatible

Safe product and/or breastfeeding is the best option.

Second-generation cephalosporin. Oral administration every 8 hours.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant. (Takase 1979)

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Expert authors consider the use of this medication to be compatible during breastfeeding (Hale, LactMed, Briggs 2015, Bar-Oz 2003, Fulton 1992). 

Alternatives

We do not have alternatives for Cefaclor since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefaclor in other languages or writings:

Group

Cefaclor belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefaclor in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 386 daltons
Protein Binding 25 %
VD 0.35 l/Kg
pKa 2.83 -
Tmax 0.5 - 1 hours
T½ 0.6 - 1 hours
Theoretical Dose 0.03 mg/Kg/d
Relative Dose 0.2 %
Ped.Relat.Dose 0.1 - 0.2 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  5. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  6. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  7. Takase Z, Shirafuji H, Uchida M. Clinical and laboratory studies of cefaclor in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1979;27(Suppl 7):666-72. 1979

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