Last update Aug. 17, 2019

Lactitol

Compatible

Safe substance and/or breastfeeding is the best option.

Synthetic derivative of lactulose. It is a disaccharide analogue of lactulose with similar action and uses.
It does not hydrolyze in the intestine, so it is not absorbed, reaching the colon intact, where it exerts its function as an osmotic laxative (AEMPS 2015, Würsch 1989, Metzger 1988). Indicated in constipation and hepatic encephalopathy.
Oral administration in a daily dose.

Since the last update we have not found published data on its excretion in breastmilk.

Its virtually zero oral bioavailability makes plasma levels null and therefore does not transfer to breastmilk (AEMPS 2015, P-RMS 2010).

For the same reason, it impedes transfer from breastmilk to infant plasma.


See below the information of this related product:

  • Lactulose (Safe substance and/or breastfeeding is the best option.)

Alternatives

We do not have alternatives for Lactitol since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Lactitol is also known as


Lactitol in other languages or writings:

Group

Lactitol belongs to this group or family:

Tradenames

Main tradenames from several countries containing Lactitol in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 1 %
Molecular weight 344 daltons
pKa 12.1 -

References

  1. AEMPS. Lactitol (Emportal). Ficha técnica. 2015 Full text (in our servers)
  2. P-RMS. Lactitol (Importal). Drug Summary. 2010 Full text (in our servers)
  3. Würsch P, Koellreutter B, Schweizer TF. Hydrogen excretion after ingestion of five different sugar alcohols and lactulose. Eur J Clin Nutr. 1989 Dec;43(12):819-25. Abstract
  4. Metzger J, Chollet C, Wermeille M, Biollaz J, Llull JB, Lauterburg BH. Lactitol: gastrointestinal absorption and effect on blood lactate in healthy volunteers and patients with cirrhosis. Eur J Clin Pharmacol. 1988;35(1):97-9. Abstract

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