Last update June 18, 2022
Very Low Risk
It is a tricyclic antidepressant with actions and uses similar to those of amitriptyline. It has marked antimuscarinic and sedative properties. It is used in the treatment of depression and obsessive-compulsive disorder. Oral administration in one or two daily doses.
Excreted into breast milk in a clinically non-significant amount (Khachman 2009, Yoshida 1997, Schimmell 1991) with no problems observed in breastfed infants from treated mothers. (Khachman 2009, Nulman 2002, Birnbaum 1999, Yoshida 1997, Wisner 1995, Schimmell 1991, Misri 1991)
Levels found in the plasma of those infants were very low or undetectable. (Khachman 2009, Birnbaum 1999, Yoshida 1997, Wisner 1995, Schimmell 1991)
Because of a tiny excretion into the milk, symptoms due to deprivation syndrome would not be avoided by breastfeeding the infants whose mothers were taking this medication during pregnancy. (ter Horst 2012, Khachman 2009)
Galactorrhea and increased plasma prolactin levels have been reported. (Cordes 2011, Egberts 1997, Fowlie 1987)
Known safer alternatives may be preferable, especially during the neonatal period and in the event of prematurity. (Sriraman 2015, Gentile 2014, Davanzo 2011, Weissman 2004, Gjerdingen 2003)
List of WHO essential medicines: compatible with breastfeeding. (WHO-UNICEF 2002)
Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. (Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
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