甲泼尼龙

It is a corticosteroid that is used to treat inflammation and immune reactions in a wide variety of diseases. Oral, intramuscular, intravenous, topical, ophthalmological, intraarticular and intralesional administration.

It is excreted into breast milk in non-significant amount ^{(Zengin 2020, Boz 2018, Gunduz 2016, Cooper 2015, Strijbos 2015)} with no problems reported in breastfed infants whose mothers were treated for a long time period. ^{(Costanzo 2020, Zengin 2020, Grekas 1984)}

Following megadoses of methylprednisolone (1 g daily) the maximum dose the infant can take through breast milk is less than half the therapeutic infant dose and with a relative dose of less than 3% ^{(Zengin 2020, Boz 2018, Gunduz 2016, Cooper 2015, Strijbos 2015)}. If you want to minimize the exposure of the infant after a megadose or in chronic treatment at doses greater than 40 mg/day, 2 to 4 hours after drug administration can be expected. ^{(Zengin 2020, Boz 2018, Gunduz 2016, Cooper 2015, Strijbos 2015)}

Intra-articular injections of methylprednisolone may temporarily decrease milk production. ^{(Babwah 2013)}

Corticosteroids such as betamethasone, administered before delivery may delay initiation of phase II of Lactogenesis ("milk come in") and decrease milk production in the first postpartum week. ^{(Henderson 2008)}

Steroid drugs are commonly used for Pediatric treatment with no side effects when infrequently used and for short-time periods.