Last update Aug. 20, 2022
Very Low Risk
It is a corticosteroid that is used to treat inflammation and immune reactions in a wide variety of diseases. Oral, intramuscular, intravenous, topical, ophthalmological, intraarticular and intralesional administration.
It is excreted into breast milk in non-significant amount (Zengin 2020, Boz 2018, Gunduz 2016, Cooper 2015, Strijbos 2015) with no problems reported in breastfed infants whose mothers were treated for a long time period. (Costanzo 2020, Zengin 2020, Grekas 1984)
Following megadoses of methylprednisolone (1 g daily) the maximum dose the infant can take through breast milk is less than half the therapeutic infant dose and with a relative dose of less than 3% (Zengin 2020, Boz 2018, Gunduz 2016, Cooper 2015, Strijbos 2015). If you want to minimize the exposure of the infant after a megadose or in chronic treatment at doses greater than 40 mg/day, 2 to 4 hours after drug administration can be expected. (Zengin 2020, Boz 2018, Gunduz 2016, Cooper 2015, Strijbos 2015)
Intra-articular injections of methylprednisolone may temporarily decrease milk production. (Babwah 2013)
Corticosteroids such as betamethasone, administered before delivery may delay initiation of phase II of Lactogenesis ("milk come in") and decrease milk production in the first postpartum week. (Henderson 2008)
Steroid drugs are commonly used for Pediatric treatment with no side effects when infrequently used and for short-time periods.
We do not have alternatives for 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM