Last update July 5, 2022

Isocarboxazid

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

It is an irreversible inhibitor of monoamine oxidase type A and B with actions and uses similar to those of phenelzine. Used in the treatment of depression. Oral administration in one or two daily doses.

Since the last update we have not found any published data on its excretion in breast milk.

The few known pharmacokinetic data do not allow to predict the possible passage into breast milk.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


See below the information of this related product:

  • Maternal Depression (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Isocarboxazid in other languages or writings:

Groups

Isocarboxazid belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Isocarboxazid in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 231 daltons
pKa 10.42 -
Tmax 3 - 5 hours
2.5 (1.5 - 4) hours

References

  1. FDA. Isocarboxazid. Drug Summary. 2018 Full text (in our servers)

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