Last update Aug. 28, 2020


Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is an angiotensin II receptor antagonist with actions similar to those of losartan.
It is indicated in the treatment of hypertension.
Oral administration once a day.

At latest update, relevant published data on excretion into breast milk were not found.

Because of a high protein-binding capacity, a significant excretion into breast milk is unlikely.

However, it is one among the Sartan drugs (ARA-II type) with the longest half-life and highest oral bioavailability (Tamargo 2006). The latter properties make it less convenient for use while breastfeeding.

Until more data on this medication is available safer alternative drugs are preferred (Rowe 2013), especially in premature babies or during the neonatal period.


  • Candesartan Cilexetil ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Captopril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Enalapril ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Quinapril Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Irbesartan in other languages or writings:


Main tradenames from several countries containing Irbesartan in its composition:


Variable Value Unit
Oral Bioavail. 60 - 80 %
Molecular weight 429 daltons
Protein Binding 96 %
VD 0.7 - 1.3 l/Kg
Tmax 1.5 - 2 hours
12 - 17 hours


  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Sano.Ave. Irbesartan. Drug Summary. 2012 Full text (in our servers)
  3. AEMPS. Irbesartán. Ficha técnica. 2008 Full text (in our servers)
  4. Tamargo j, Caballero R, Gómez R, Núñez L, Vaquero M y Delpón E. Características farmacológicas de los ARA-II. ¿Son todos iguales?. Rev Esp Cardiol Supl. 2006;6:10C-24C. 2006 Full text (in our servers)

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM