Last update June 15, 2022

Iloperidone

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is an atypical antipsychotic (second generation antipsychotics and serotonin–dopamine antagonists). It is used in the treatment of schizophrenia. Oral administration in two daily doses.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very high percentage of protein binding and very wide volume of distribution) make it highly unlikely that significant quantities will pass into breast milk.

Iloperidone has little or no significant effect on prolactin levels. (Peuskens 2014) 

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

Alternatives

  • Olanzapine (Safe substance and/or breastfeeding is the best option.)
  • Quetiapine Fumarate (Safe substance and/or breastfeeding is the best option.)
  • Risperidone (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Iloperidone in other languages or writings:

Groups

Iloperidone belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Iloperidone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 96 %
Molecular weight 427 daltons
Protein Binding 95 %
VD 19 - 40 l/Kg
pKa 16.14 -
Tmax 2 - 4 hours
18 - 33 hours

References

  1. FDA. Iloperidone. Drug Summary. 2016 Full text (in our servers)
  2. Peuskens J, Pani L, Detraux J, De Hert M. The effects of novel and newly approved antipsychotics on serum prolactin levels: a comprehensive review. CNS Drugs. 2014 May;28(5):421-53. Abstract Full text (link to original source)

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