Last update Aug. 24, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
Human von Willebrand factor (vWF) is also known as
Human von Willebrand factor (vWF) in other languages or writings:
Human von Willebrand factor (vWF) belongs to this group or family:
Main tradenames from several countries containing Human von Willebrand factor (vWF) in its composition:
|Molecular weight||250.000 - 20.000.000||daltons|
|T½||16.5 ± 4.1||hours|
Write us at firstname.lastname@example.org
e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Human von Willebrand factor is a plasma glycoprotein of 2,050 amino acids that acts as a blood coagulation factor. Vonicog alfa is a recombinant form of human von Willebrand factor. It is used to control bleeding episodes in von Willebrand disease and, along with factor VIII, hemophilia A. Intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
Its very high molecular weigh and its binding to coagulation factor VIII make it highly unlikely that significant quantities will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.
Expert authors consider the use of this medication probably compatible during breastfeeding. (Hale). According to the WHO list of essential drugs, coagulation factors with a similar glycoprotein structure and high molecular weight, such as factor II, VII, VIII, IX and X, are compatible with breastfeeding. (WHO 2002)