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Human von Willebrand factor is a plasma glycoprotein of 2,050 amino acids that acts as a blood coagulation factor. Vonicog alfa is a recombinant form of human von Willebrand factor. It is used to control bleeding episodes in von Willebrand disease and, along with factor VIII, hemophilia A. Intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
Its very high molecular weigh and its binding to coagulation factor VIII make it highly unlikely that significant quantities will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.
Expert authors consider the use of this medication probably compatible during breastfeeding. (Hale). According to the WHO list of essential drugs, coagulation factors with a similar glycoprotein structure and high molecular weight, such as factor II, VII, VIII, IX and X, are compatible with breastfeeding. (WHO 2002)