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It is a quaternary ammonium with antimuscarinic effects similar to those of atropine. It is used in anesthetic practice, in the treatment of hyperhidrosis, peptic ulcer, severe chronic drooling in children, and as a bronchodilator in chronic obstructive pulmonary disease. Oral, dermatological topical, inhaled, intramuscular or intravenous administration.
At the date of the last update we did not find any published data on its excretion in breast milk.
Its wide volume of distribution makes it difficult to pass into breast milk.
Its low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.
Although antimuscarinics can decrease prolactin production (Müller 1983, Masala 1982), once lactation is established, milk production depends more on the repeated stimulation of suckling than on prolactin levels.
Its use is authorized for children from one year of age.
Several medical societies and experts authors consider the use of this medication to be safe or very probably safe during breastfeeding. (Reece 2017, Cobb 2015, Dalal 2014, Lee 1993)