Last update Jan. 16, 2021

Gliclazide

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Sulfonylurea that stimulates endogenous insulin secretion. May cause hypoglycemia.
Indicated in the treatment of type 2 diabetes.
Oral administration, one daily dose

We did not find published data regarding the excretion of this substance through breast milk at the time this last update was completed.

Its pharmacokinetic characteristics (very high plasma protein binding and large volume of distribution) make it very unlikely its excretion into breast milk in significant amounts.

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

Diet, exercise, and breastfeeding improve blood sugar levels.


See below the information of this related product:

Alternatives

  • Acarbose ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Glibenclamide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hypocaloric Diet ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Insulin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Maternal Sport ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metformin Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Miglitol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Gliclazide in other languages or writings:

Tradenames

Main tradenames from several countries containing Gliclazide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 323 daltons
Protein Binding 95 %
VD 0.43 l/Kg
pKa 4.07 -
Tmax 4 - 6 hours
16 (10 - 20) hours

References

  1. AEMPS. Gliclazida. Ficha técnica. 2020 Full text (in our servers)
  2. AA Pharma. Gliclazide. Drug Summary. 2010 Full text (in our servers)

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