Last update June 4, 2016

氟曲马唑

Compatible

Safe product and/or breastfeeding is the best option.

At latest update no published data on excretion into breast milk were found.

Excretion into breast milk is highly unlikely due to the low absorption through the skin (1%) or vaginal mucosa (8%) and hence a low presence into the blood.

Whenever used on the nipple apply it after feeding and remove excess of cream before the next meal.

It should be avoided the use on the nipple of creams, gels and other products for local application containing paraffin (mineral oil) to keep the infant off from absorption.

Alternatives

We do not have alternatives for 氟曲马唑 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

氟曲马唑 is Flutrimazole in Chinese.

Is written in other languages:

Groups

氟曲马唑 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing 氟曲马唑 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 1 (dermat) %
Molecular weight 346 daltons
Tmax 28 hours
T½ 37 hours

References

  1. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  2. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  3. John B, Wood SG, Ramis J, Izquierdo I, Forn J. Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women. Arzneimittelforschung. 1998 Abstract
  4. Ramis J, Conte L, Segado X, Forn J, Lauroba J, Calpena A, Escribano E, Domenech J. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997 Abstract
  5. Duchène P, Papalexiou P, Ramis J, Izquierdo I, Houin G. Pharmacokinetic profile of [14C]flutrimazole following single topical application in normal and scarified skin of healthy volunteers. Arzneimittelforschung. 1992 Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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