Last update June 4, 2016



Safe substance and/or breastfeeding is the best option.

At latest update no published data on excretion into breast milk were found.

Excretion into breast milk is highly unlikely due to the low absorption through the skin (1%) or vaginal mucosa (8%) and hence a low presence into the blood.

Whenever used on the nipple apply it after feeding and remove excess of cream before the next meal.

It should be avoided the use on the nipple of creams, gels and other products for local application containing paraffin (mineral oil) to keep the infant off from absorption.


We do not have alternatives for C22H16F2N2 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C22H16F2N2 is Flutrimazole in Molecular formula.

Is written in other languages:


Main tradenames from several countries containing C22H16F2N2 in its composition:


Variable Value Unit
Oral Bioavail. 1 (dermat) %
Molecular weight 346 daltons
Tmax 28 hours
37 hours


  1. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  2. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  3. John B, Wood SG, Ramis J, Izquierdo I, Forn J. Absorption and excretion of radioactivity after intravaginal administration of an advanced delivery system of 14C-flutrimazole vaginal cream to postmenopausal women. Arzneimittelforschung. 1998 Abstract
  4. Ramis J, Conte L, Segado X, Forn J, Lauroba J, Calpena A, Escribano E, Domenech J. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997 Abstract
  5. Duchène P, Papalexiou P, Ramis J, Izquierdo I, Houin G. Pharmacokinetic profile of [14C]flutrimazole following single topical application in normal and scarified skin of healthy volunteers. Arzneimittelforschung. 1992 Abstract

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e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM