Last update Aug. 3, 2022

Фосфомицин Трометамол

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Fosfomycin is a bactericidal antibacterial indicated in the treatment of uncomplicated acute cystitis in adult women and adolescents. One to three time daily oral administration for one to three days. Possible intravenous administration.

It is excreted in human milk in insignificant amounts. (Kirby 1977)

Its use is approved in infants less than one year of age.

Its low oral bioavailability makes it difficult for the infant to pass into plasma from ingested mothers’ milk, except in premature infants and during the immediate neonatal period in which there may be greater intestinal permeability.

Food and calcium in the mothers’ milk make intestinal absorption even more difficult (Hale); calcium fosfomycin is very poorly absorbed. (Lebedevs 2020, Bergan 1990)

Although rare, the possibility of transient gastroenteritis due to altered intestinal flora should be considered in infants whose mothers take antibiotics. (Briggs 2015, Benyamini 2005)

Alternatives

We do not have alternatives for Фосфомицин Трометамол since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Фосфомицин Трометамол is Fosfomycin Trometamol, Fosfomycin Tromethamine in Cyrillic.

Is written in other languages:

Фосфомицин Трометамол is also known as

Group

Фосфомицин Трометамол belongs to this group or family:

Tradenames

Main tradenames from several countries containing Фосфомицин Трометамол in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Trom: 30 - 58; Calc: 12 %
Molecular weight 259 daltons
Protein Binding 1 %
VD 1.9 ± 0.6 l/Kg
pKa 1.25 -
Tmax 2 - 4 hours
4 - 6 hours
M/P ratio 0.1 -
Theoretical Dose 0.54 - 0.72 mg/Kg/d
Relative Dose 1.6 - 4.3 %
Ped.Relat.Dose 0.27 - 0.72 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. AEMPS Fosfomicina Ficha técnica 2020 Full text (in our servers)
  3. Lebedevs T. Fosfomycin and breastfeeding. Aust Prescr. 2020 Aug;43(4):113. Abstract Full text (link to original source)
  4. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  5. FDA. Fosfomycin Drug Summary 2007 Full text (in our servers)
  6. Gobernado M. [Fosfomycin]. Rev Esp Quimioter. 2003 Abstract Full text (link to original source) Full text (in our servers)
  7. Bergan T. Pharmacokinetic comparison between fosfomycin and other phosphonic acid derivatives. Chemotherapy. 1990 Abstract
  8. Bergan T. Degree of absorption, pharmacokinetics of fosfomycin trometamol and duration of urinary antibacterial activity. Infection. 1990 Abstract
  9. Kirby WM. Pharmacokinetics of fosfomycin. Chemotherapy. 1977 Abstract

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