Fluvoxamine Maleate

SSRI antidepressant with actions and uses similar to those of fluoxetine. Oral administration once or twice daily.

It is excreted in breast milk in small amounts. ^{(Weisskopf 2017, Kristensen 2002, Arnold 2000, Hägg 2000, Yoshida 1997, Wright 1991)}

Serum levels of infants from breastfeeding mothers who were treated have been shown to be undetectable or very low. ^{(Kristensen 2002, Piontek 2001, Hendrick 2001) with some exception (Arnold 2000)}

Although there are some isolated case of gastroenteritis ^{(Uguz 2015)}, no short-term or long-term problems have been observed in the majority of infants whose mothers took it. ^{(Gentile 2006, Kristensen 2002, Hendrick 2003 y 2001, Arnold 2000, Yoshida 1997, Wright 1991)}

Neonatal poor adaptation problems have not been observed during the immediate neonatal period, in term or preterm infants whose mothers took fluvoxamine during pregnancy. ^{(Kieviet 2015)}

Galactorrhea associated or not to hyperprolactinemia, may appear. ^{(Bhattacharjee 2021, Chakladar 2020, Trenque 2011, Egberts 1997)}

Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding. ^{(Hale, Lactmed, Uguz 2021, Sriraman 2015, Orsolini 2015, Rowe 2013, Davanzo 2011, Berle 2011, Patil 2011, Lanza 2011, Gentile 2005, Rubin 2004, Gjerdingen 2003, Nordeng 2001)}

Safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity. ^{(Weissman 2004)}

Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. ^{(Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)}

See below the information of this related product:

• Maternal Depression (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)