Last update June 23, 2022

Fluphenazine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Typical, first-generation antipsychotic. Prochlorperazine is a phenothiazine derivative with general properties similar to those of chlorpromazine. It is used in the treatment of schizophrenia, bipolar disorder, and severe anxiety. Oral, intramuscular or subcutaneous administration three or four times a day.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data (very wide volume of distribution and high percentage of protein binding) make it highly unlikely that significant quantities will pass into breast milk.

Its very low oral bioavailability makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Parikh 2014, Klinger 2013, WHO 2002), especially during the neonatal period and in the event of prematurity.

During breastfeeding, depot forms should be avoided because their long half-life can facilitate greater excretion in breast milk.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Fluphenazine is also known as


Fluphenazine in other languages or writings:

Groups

Fluphenazine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Fluphenazine in its composition:

List of 10 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 2.7 %
Molecular weight 438 daltons
Protein Binding 99 %
VD 3 l/Kg
pKa 15.59 -
Tmax 2; depot: 8-10 hours
T½ 4.4 - 16.4; depot: 336 hours

References

  1. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  2. Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. Abstract
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)

Total visits

5,308

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM