Last update Feb. 7, 2025

Flufenamic Acid

Compatible

Safe product and/or breastfeeding is the best option.

Nonsteroidal anti-inflammatory drug for topical use related to mefenamic acid. Precursor of etofenamate. Oral forms of administration are also available.

Excreted in breast milk in negligible, clinically insignificant amount, even after oral administration. The milk/plasma ratio is 0.01.(Buchanan 1969)

The small dose and poor plasma absorption of most topical dermatological preparations make passage of significant amount into blood plasma and even less into breast milk unlikely. 

American Academy of Pediatrics: medication usually compatible with breastfeeding. (AAP 2001)


See below the information of this related product:

  • Etofenamate (Safe product and/or breastfeeding is the best option.)

Alternatives

  • Ibuprofen (Safe product and/or breastfeeding is the best option.)
  • Paracetamol (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Flufenamic Acid in other languages or writings:

Group

Flufenamic Acid belongs to this group or family:

Tradenames

Main tradenames from several countries containing Flufenamic Acid in its composition:

List of 11 tradenames

Pharmacokinetics

Variable Value Unit
Molecular weight 281 daltons
VD > 0.5 l/Kg
pKa 3.88 -
Tmax 1.5 hours
T½ 5 - 22 hours
M/P ratio 0.01 -
Theoretical Dose 0.008 mg/Kg/d
Relative Dose 0.08 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Lentjes EG, van Ginneken CA. Pharmacokinetics of flufenamic acid in man. Int J Clin Pharmacol Ther Toxicol. 1987 Abstract
  3. Buchanan RA, Eaton CJ, Koeff ST, Kinkel AW. The breast milk excretion on flufenamic acid. Curr Ther Res Clin Exp. 1969 Abstract

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