Last update Feb. 5, 2025

Etofenamate

Compatible

Safe product and/or breastfeeding is the best option.

Nonsteroidal anti-inflammatory derived from flufenamic acid, which is its precursor. Topical use, although there are also oral and intramuscular forms of administration.

It is excreted in breast milk in negligible quantity: after an oral dose of 300 mg, less than 14 picograms in total of flufenamic acid were excreted in milk.  (Dell 1983)

Flufenamic acid passes into milk in a clinically insignificant amount and is considered by the American Academy of Pediatrics as a medication usually compatible with breastfeeding. (AAP 2001)

Plasma absorption through the skin has been proven (Bender 2001). Its high binding to plasma proteins makes it unlikely to pass into milk.

If used, do not apply to the breast or to large areas or for prolonged periods to avoid systemic absorption.


See below the information of this related product:

Alternatives

  • Flufenamic Acid (Safe product and/or breastfeeding is the best option.)
  • Ibuprofen (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Etofenamate in other languages or writings:

Group

Etofenamate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Etofenamate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 21 (dermal) %
Molecular weight 369 daltons
Protein Binding 99 %
Tmax 2 - 5.6 hours
T½ 1.6 - 3.3 hours

References

  1. Bayer. Etofenamato. Ficha técnica. 2011 Full text (in our servers)
  2. Bender T, Bariska J, Rojkovich B, Bálint G. Etofenamate levels in human serum and synovial fluid following iontophoresis. Arzneimittelforschung. 2001 Abstract
  3. Herrera GL, Guevara LU, Torres GRA. Etofenamato: Características farmacologícas y clinicas de la formulación intramuscular. Rev Mex Anest 2001; 24 (4) 2001 Full text (link to original source) Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Dell HD, Beckermann B, Fiedler J, Kamp R. [Renal elimination and metabolism of etofenamate in volunteers after administration of various doses]. Arzneimittelforschung. 1990 Abstract
  6. Beckermann B, Bock E, Kamp R, Dell HD. [Plasma level studies in volunteers after intramuscular injection of various doses of etofenamate in an oily solution]. Arzneimittelforschung. 1990 Abstract
  7. Dell HD, Fiedler J. [A test for excretion of etofenamate into milk]. Arch Pharm (Weinheim). 1983 Abstract

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