Last update Nov. 22, 2022
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 100 | % |
Molecular weight | 204 | daltons |
Protein Binding | 41 | % |
pKa | 11.18 | - |
Tmax | 1 - 2 | hours |
T½ | 5 (3 - 9) | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is a hydantoin antiepileptic with actions similar to those of phenytoin, although less effective. Oral administration 4 to 6 times a day.
At the date of the last update, we found no published data on its excretion in breast milk.
Its pharmacokinetic data (low molecular weight and low percentage of plasma protein binding) makes it likely that significant amounts will pass into breast milk.
There are very few bibiographical references which are also very old, and it is sold in few countries.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.