Last update Nov. 22, 2022

Ethotoin

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a  hydantoin antiepileptic with actions similar to those of phenytoin, although less effective. Oral administration 4 to 6 times a day.

At the date of the last update, we found no published data on its excretion in breast milk.

Its pharmacokinetic data (low molecular weight and low percentage of plasma protein binding) makes it likely that significant amounts will pass into breast milk.

There are very few bibiographical references which are also very old, and it is sold in few countries.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ethotoin in other languages or writings:

Group

Ethotoin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ethotoin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 204 daltons
Protein Binding 41 %
pKa 11.18 -
Tmax 1 - 2 hours
5 (3 - 9) hours

References

  1. Troupin AS, Friel P, Lovely MP, Wilensky AJ. Clinical pharmacology of mephenytoin and ethotoin. Ann Neurol. 1979 Nov;6(5):410-4. Abstract

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