Last update Aug. 18, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Phenytoin is also known as
Phenytoin in other languages or writings:
Phenytoin belongs to this group or family:
Main tradenames from several countries containing Phenytoin in its composition:
|Oral Bioavail.||70 - 100||%|
|VD||0.5 - 0.8||l/Kg|
|Tmax||1.5 - 3 / 4 - 12||hours|
|T½||oral: 22 (7 - 42). / iv: 7-15||hours|
|M/P ratio||0.2 - 0.5||-|
|Theoretical Dose||0.07 - 0.4||mg/Kg/d|
|Relative Dose||1.4 - 8||%|
|Ped.Relat.Dose||1 - 7||%|
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is an antiepileptic that is used to control the seizures of epilepsy and trigeminal neuralgia. It is also a class Ib antiarrhythmic that has been used to treat cardiac arrhythmias. Oral and intravenous administration.
It is excreted into breast milk in clinically non-significant amount (Bar-Oz 2000, Shimoyama 1998, Meyer 1988, Söderman 1988, Kaneko 1979, Rane 1974, Mirkin 1971)
No problems have appeared on clinical follow up, and, long-term psychomotor development in infants whose mothers received this treatment. (Meador 2014 & 2010, Mirkin 1971, LIvingston 1956)
Plasma levels in these infants were undetectable or very low. (Steen 1982)
It may appear a withdrawal syndrome with hyperexcitability after abruptly stopping breastfeeding.
It has been authorized for use in infants and newborns.
Expert authors consider the use of this medication safe during lactation (Hale, LactMed, Crettenand 2018, Briggs 2015, Schaefer 2015, Rowe 2013, Davanzo 2013, Mercadé 2012, Mintzer 2011, Harden 2009, O'Connor 2009, Pennell 2006, O'Brien 2005, Hägg 2000)). American Academy of Pediatrics states that it is usually compatible with breastfeeding medication (AAP 2001). WHO List of Essential Medicines 2002: compatible with breastfeeding. (WHO 2002)