Last update Dec. 8, 2017

Ertapénem Sodique

Compatible

Safe product and/or breastfeeding is the best option.

Antibacterial carbapenem beta-lactam with indications similar to imipenem.
Intravenous administration a daily dose.

It is excreted in breast milk in a clinically insignificant amount (Merck 2012).

Authorized pediatric use in infants from 3 months of age.

Its low oral bioavailability would make it difficult for it to pass to the infant’s plasma ingesting breast milk, except in preterm infants and in the immediate neonatal period when there may be increased intestinal permeability.

The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to altered intestinal flora (Benyamini 2005, Ito 1993, Kafetzis 1981).

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Ertapénem Sodique is Ertapenem Sodium in French.

Is written in other languages:

Group

Ertapénem Sodique belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ertapénem Sodique in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 498 daltons
Protein Binding 95 %
VD 0.11 l/Kg
pKa 4.05 -
Tmax 0.5 hours
T½ 4 hours
Theoretical Dose 0.057 mg/Kg/d
Relative Dose 0.34 %

References

  1. EMA. Ertapenem. Ficha técnica. 2017 Full text (in our servers)
  2. Merck. Ertapenem. Drug Summary. 2012 Full text (in our servers)
  3. Benyamini L, Merlob P, Stahl B, Braunstein R, Bortnik O, Bulkowstein M, Zimmerman D, Berkovitch M. The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Ther Drug Monit. 2005 Abstract
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  5. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract

Total visits

1,995

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by IHAN of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM