Last update Aug. 17, 2019


Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

A polyphenol (3,5,4’-trihydroxystilbene) derived from grapes and other vegetables such as arachis (peanut), pinus, veratrum and fallopia japonica (polygonum cuspidatum; reynoutria japonica, hu zhang).
It is found in musts and wines in variable but small quantities.

It is a bioflavonoid to which are attributed these properties: antioxidant, venoprotective, cardioprotective, properties against arteriosclerosis, acne and cancer, among others. None of these properties has been sufficiently proven (MedlinePlus 2018).

Since the last update we have not found published data on its excretion in breastmilk.

Oral bioavailability is very low: although it is well absorbed in the intestine, a first-pass metabolism makes the concentration of resveratrol in plasma insignificant (Almeida 2009, Wenzel 2005, Walle 2004).
This low oral bioavailability means that significant amounts cannot transfer to breastmilk. For the same reason, transfer from breastmilk to infant plasma is impeded, except in premature infants and the immediate neonatal period when there may be greater intestinal permeability.

Resveratrol from food and supplements taken orally at non-high doses would be compatible with breastfeeding.

It inhibits prolactin secretion in vitro (Wang 2012).

See below the information of this related product:

  • Grapevine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)


We do not have alternatives for (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol is Resveratrol in Chemical name.

Is written in other languages:

(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol is also known as


(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol belongs to this group or family:


Main tradenames from several countries containing (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition:

  • Biogel Resv™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition
  • For-Age™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition
  • Framintrol™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition
  • Resveragen
  • Resverasor™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition
  • Revidox
  • Scortrol™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition
  • Synthol™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition
  • Zumo de Goji con OXY3™. Contains other elements than (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol in its composition


Variable Value Unit
Oral Bioavail. < 2 %
Molecular weight 228 daltons
pKa 8.49 -
Tmax 1 - 1.5 hours
1 - 15 hours


  1. MedlinePlus. Resveratrol. Información de salud para usted. 2018 Full text (link to original source) Full text (in our servers)
  2. MedlinePlus. Resveratrol. Health information for you. 2018 Full text (link to original source) Full text (in our servers)
  3. Wang C, Hu ZQ, Chu M, Wang Z, Zhang WG, Wang LZ, Li CG, Wang JS. Resveratrol inhibited GH3 cell growth and decreased prolactin level via estrogen receptors. Clin Neurol Neurosurg. 2012 Apr;114(3):241-8. Abstract
  4. Almeida L, Vaz-da-Silva M, Falcão A, Soares E, Costa R, Loureiro AI, Fernandes-Lopes C, Rocha JF, Nunes T, Wright L, Soares-da-Silva P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res. 2009 May;53 Suppl 1:S7-15. Abstract
  5. Wenzel E, Somoza V. Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res. 2005 May;49(5):472-81. Review. Abstract
  6. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82. Epub 2004 Aug 27. Abstract

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