Last update Dec. 20, 2021

Dulaglutide

Compatible

Safe substance and/or breastfeeding is the best option.

Long-acting agonist of the glucagon-like peptide receptor type 1 (GLP-1) that stimulates the endogenous secretion of insulin and decreases that of glucagon. Used in type 2 diabetes in combination with other oral anti-diabetics, especially metformin. Subcutaneous administration once a week. There is risk of hypoglycaemia even in monotherapy.

Since the last update, we have not found published data on its excretion in breast milk.

Its high molecular weight make it very unlikely that significant amounts will pass into breast milk. (Serrano 2014)

Due to its protein nature, it deteriorates in the gastrointestinal tract, not being absorbed (Serrano 2014). This low oral bioavailability would make it difficult for it to pass to the infant’s plasma ingesting breast milk, except in preterm infants and in the immediate neonatal period when there may be increased intestinal permeability.

Diet, exercise, and breastfeeding improve blood sugar levels.


See below the information of this related product:

  • Maternal Diabetes mellitus (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Acarbose (Safe substance and/or breastfeeding is the best option.)
  • Chlorpropamide (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Exenatide (Safe substance and/or breastfeeding is the best option.)
  • Glibenclamide (Safe substance and/or breastfeeding is the best option.)
  • Hypocaloric Diet (Safe substance and/or breastfeeding is the best option.)
  • Maternal Sport (Safe substance and/or breastfeeding is the best option.)
  • Metformin Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Miglitol (Safe substance and/or breastfeeding is the best option.)
  • Tolbutamide (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dulaglutide in other languages or writings:

  • دولاقلوتيد (Arabic)
  • Дулаглутид (Cyrillic)
  • Dulaglutide (French)
  • ドゥラグルチド (Japanese)
  • LY-2189265 (Experimental code/s)
  • 7-37-Glucagon-like peptide 1 [8-glycine,22-glutamic acid,36-glycine] (synthetic human) fusion protein with peptide (synthetic 16-amino acid linker) fusion protein with immunoglobulin G4 (synthetic human Fc fragment), dimer (Chemical name)
  • C2646H4044N704O836S18 (Molecular formula)
  • A10BJ05 (ATC Code/s)

Tradenames

Main tradenames from several countries containing Dulaglutide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 59.670 daltons
VD 0.27 l/Kg
Tmax 48 (24 - 72) hours
120 hours

References

  1. EMA. Dulaglutide. Drug Summary. 2017 Full text (in our servers)
  2. EMA. Dulaglutida. Ficha técnica. 2017 Full text (in our servers)
  3. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Jan 20;144(2):73-9. Abstract

Total visits

5,335

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM