Last update Nov. 28, 2020

Diphencyprone (DPCP)

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Uso tópico como sensibilizante de contacto en el tratamiento de la alopecia areata y las verrugas.

A fecha de última actualización no encontramos datos publicados sobre su excreción en leche materna.

La pequeña dosis y la escasa absorción plasmática de la mayoría de preparaciones dermatológicas tópicas hacen poco probable el paso de cantidad significativa a leche materna.
Se cree que tiene muy escasa absorción sistémica (PSM 2020), pero no hay datos publicados sobre la misma. Los efectos secundarios descritos son secundarios a la irritación local, no habiéndose descrito efectos sistémicos (Kuin 2015, Luk 2013)
Se ha utilizado en niños entre 4 meses y 18 años sin efectos secundarios de tipo sistémico (Salsberg 2012).

Hasta conocer más datos publicados sobre este fármaco en relación con la lactancia, pueden ser preferibles alternativas conocidas más seguras, especialmente durante el periodo neonatal y en caso de prematuridad.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Diphencyprone (DPCP) in other languages or writings:

Group

Diphencyprone (DPCP) belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Molecular weight 206 daltons

References

  1. PSM - Parc de Salut Mar. Difenciprona para la alopecia areata. 2020 Full text (link to original source) Full text (in our servers)
  2. Kuin RA, Spuls PI, Limpens J, van Zuuren EJ. Diphenylcyclopropenone in patients with alopecia areata. A critically appraised topic. Br J Dermatol. 2015 Oct;173(4):896-909. Abstract
  3. Luk NM, Chiu LS, Lee KC, Chau CT, Lee VW, Chang M, Lam YK, Lee HC. Efficacy and safety of diphenylcyclopropenone among Chinese patients with steroid resistant and extensive alopecia areata. J Eur Acad Dermatol Venereol. 2013 Mar;27(3):e400-5. Abstract
  4. Salsberg JM, Donovan J. The safety and efficacy of diphencyprone for the treatment of alopecia areata in children. Arch Dermatol. 2012 Sep;148(9):1084-5. Abstract

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