Last update Sept. 27, 2015

Clobetasol Propionate

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Topical corticosteroid with a very high strength.

At latest update it was not found published data on excretion into breast milk.
The small dose and poor absorption into plasma of most topical dermatological preparations make it unlikely any passage of significant amount in the breast milk.

If required to treat eczema or dermatitis of the nipple, it should be chosen lower strength steroids, apply it just after finishing the meal to let it be absorbed before the next meal, if necessary remove any excess with a gauze and avoid using it continuously for longer than a week.

Steroidal poisoning has occurred in an infant by continuous application of a corticosteroid in the nipple.

Avoid applying creams, gels and other products for local application on the nipple that contain paraffin (mineral oil) so that the baby does not absorb it.

Alternatives

We do not have alternatives for Clobetasol Propionate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Clobetasol Propionate is also known as


Clobetasol Propionate in other languages or writings:

Group

Clobetasol Propionate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Clobetasol Propionate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 467 daltons

References

  1. Barrett ME, Heller MM, Fullerton Stone H, Murase JE. Dermatoses of the breast in lactation. Dermatol Ther. 2013 Abstract
  2. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Feb;39(2):168-71. Abstract
  3. Heller MM, Fullerton-Stone H, Murase JE. Caring for new mothers: diagnosis, management and treatment of nipple dermatitis in breastfeeding mothers. Int J Dermatol. 2012 Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  6. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

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