Last update Aug. 16, 2022
It is an opioid analgesic related to codeine, with similar analgesic activity. It is used for the relief of moderate to severe pain, often in combination preparations with acetaminophen. It has also been used as a cough suppressant. Oral, subcutaneous or intramuscular administration three to four times a day. The enzyme cytochrome P450-CYP2D6 catalyzes its metabolization into dehydromorphine.
Since the last update we have not found published data on its excretion in breastmilk.
A two-day-old newborn, whose mother was taking dihydrocodeine for a cough, developed respiratory depression that required hospitalization. (Eleftheriou 2014)
Codeine is excreted into breast milk in non-significant amount, however, serious health problems have appeared among off-spring of mothers who are rapid metabolizers from Codeine to Morphine.
Discontinue if excessive sedation appears in mother or infant, and, do not administer if such a background in mother or family is present, as there are between 1% and 29% of people who are rapid metabolizers from codeine to morphine with an excess of the gene linked to enzyme P450-CYP2D6.
Ibuprofen is more effective than dihydocodeine for pain relief. (Edwards 2000)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America
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