Last update Aug. 11, 2020

Dapagliflozin

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Dapagliflozin is a selective and reversible inhibitor of the sodium and glucose co-transporter 2 (SGLT2). It acts by reducing the renal reabsorption of glucose and increasing its elimination via urine (Kasichayanula 2014, Plosker 2014).
Administered orally once a day.

Since the last update, we have not found published data on its excretion in breast milk.

Its pharmacokinetic characteristics (moderately elevated molecular weight, high plasma protein binding and large volume of distribution: EMA 2017), make it very unlikely its excretion into breast milk in significant amounts.

It has a low risk of hypoglycemia in monotherapy, which increases when it is associated with other hypoglycaemic agents (EMA 2017, Plosker 2014).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Diet, exercise and breastfeeding improve blood glucose levels.


See below the information of this related product:

Alternatives

  • Acarbose ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Glibenclamide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Glipizide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hypocaloric Diet ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Maternal Sport ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metformin Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Miglitol ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Tolbutamide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dapagliflozin is also known as


Dapagliflozin in other languages or writings:

Group

Dapagliflozin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Dapagliflozin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 78 %
Molecular weight 409 daltons
Protein Binding 91 %
VD 1.7 l/Kg
Tmax 1 - 2 hours
12.9 - 13.8 hours

References

  1. EMA. Dapagliflozina. Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Dapagliflozin. Drug Summary. 2017 Full text (in our servers)
  3. Plosker GL. Dapagliflozin: a review of its use in patients with type 2 diabetes. Drugs. 2014 Abstract
  4. Kasichayanula S, Liu X, Lacreta F, Griffen SC, Boulton DW. Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Abstract

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