Last update May 29, 2022

Cinitapride

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a substituted Benzamide drug that is similar to Cisapride. It is used in functional dyspepsia. Oral administration three times a day. (Du 2014, Baqai 2013

At latest update no published data on excretion into breast milk were found.

Drug that is poorly documented in the scientific literature. It seems to be lacking of side effects (QT-interval prolongation, cardiac arrhythmias) that led to the withdrawal of Cisapride. (Castro 2011, Mearín 2010, Portincasa 2009, Robert 2007) 

Until more published information about this drug regarding breastfeeding appears, it may be preferable a known and safer alternative, especially during the neonatal period and in cases of prematurity.

Alternatives

  • Domperidone ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Metoclopramide ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cinitapride in other languages or writings:

Group

Cinitapride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cinitapride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 403 daltons
pKa 13.62 -
Tmax 2 hours
3 - 5 hours

References

  1. Du Y, Su T, Song X, Gao J, Zou D, Zuo C, Xie W, Wang B, Zhang Z, Xu J, Tian D, Luo H, Zhang Z, Wang S, Chen J, Guo J, Gong L, Ding Y, Li Z. Efficacy and safety of cinitapride in the treatment of mild to moderate postprandial distress syndrome-predominant functional dyspepsia. J Clin Gastroenterol. 2014 Abstract
  2. Baqai MT, Malik MN, Ziauddin F. Efficacy and safety of cinitapride in functional dyspepsia. J Pak Med Assoc. 2013 Abstract
  3. Castro FJ, Saavedra J, López F, Herrera S, Bragulat E. [Acute cinitapride poisoning]. Gastroenterol Hepatol. 2011 Abstract
  4. Mearín F, Plazas MJ, Mas M, Heras J. [Cardiac safety of cinitapride]. Gastroenterol Hepatol. 2010 Abstract
  5. Portincasa P, Mearin F, Robert M, Plazas MJ, Mas M, Heras J. [Efficacy and tolerability of cinitapride in the treatment of functional dyspepsia and delayed gastric emptying]. Gastroenterol Hepatol. 2009 Abstract
  6. Robert M, Salvà M, Segarra R, Pavesi M, Esbri R, Roberts D, Golor G. The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole. Drug Metab Dispos. 2007 Abstract

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