Last update June 1, 2017

Ciclesonide

Compatible

Safe substance and/or breastfeeding is the best option.

Since the last update we have not found published data regarding breastfeeding, but its pharmacokinetic characteristics (low systemic absorption, moderately elevated molecular weight, high plasma protein binding and large volume of distribution, AEMPS 2014, FDA 2012) make it very unlikely its excretion into breast milk in significant amounts and its subsequent absorption by the infant.

At normal doses it is very rarely absorbed orally or via inhalation (nasal or pulmonary), and does not reach significant levels in plasma (FDA 2012).

Experts in breastfeeding and medication consider topical, oral or inhaled corticosteroids to be compatible with breastfeeding (National Asthma Education 2004, Ellsworth 1994, Greenberger 1987).

Alternatives

  • Budesonide (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ciclesonide in other languages or writings:

Groups

Ciclesonide belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Ciclesonide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. oral <1. inhal. 22 %
Molecular weight 541 daltons
Protein Binding 99 %
VD 2.9 l/Kg
Tmax 1 hours
T½ 6 - 7 hours

References

  1. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  2. AEMPS. Ciclesonida. Ficha técnica. 2014 Full text (in our servers)
  3. FDA. Ciclesonide. Drug Summary. 2012 Full text (in our servers)
  4. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  5. Ellsworth A. Pharmacotherapy of asthma while breastfeeding. J Hum Lact. 1994 Abstract

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