Last update May 24, 2025

Ceftaroline Fosamil Acetate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Fifth generation cephalosporin antibiotic. Injectable, parenteral administration.

At latest update no published data on excretion into breast milk were found.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view (Rowe 2013, Fulton 1992) without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (LactMed, Briggs 2015) 

Alternatives

  • Amoxicillin-Clavulanate (Safe product and/or breastfeeding is the best option.)
  • Cefadroxil (Safe product and/or breastfeeding is the best option.)
  • Cephalexin (Safe product and/or breastfeeding is the best option.)
  • Vancomycin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ceftaroline Fosamil Acetate in other languages or writings:

  • Цефтаролина Фозамил Ацетат (Cyrillic)
  • (6R,7R)-7-({(2Z)-(Ethoxyimino)[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl}amino)-3-{[4-(1-methylpyridinium-4-yl)thiazol-2-yl]sulfanyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylate monoacetate monohydrate (Chemical name)
  • C22H21N8O8PS4 (Molecular formula)
  • J01DI02 (ATC Code/s)

Group

Ceftaroline Fosamil Acetate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceftaroline Fosamil Acetate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 763 daltons
Protein Binding 20 %
VD 0.29 l/Kg
Tmax 0.9 hours
1.6 - 2.7 hours

References

  1. EMA. Ceftarolina. Ficha técnica. 2016 Full text (in our servers)
  2. EMA. Ceftaroline. Druf Summary. 2016 Full text (in our servers)
  3. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  5. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract

Total visits

6,031

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child´s Health in Greece

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM