Last update Oct. 15, 2016

Ceforanide

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Second-generation cephalosporins for injection or parenteral administration.

At latest update no published data on excretion into breast milk were found.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Ceforanide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ceforanide in other languages or writings:

Group

Ceforanide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceforanide in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 520 daltons
Protein Binding 81 %
VD 0.17 l/Kg
T½ 2.2 - 2.9 hours

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  4. Thirumoorthi MC, Buckley JA, Vincent CV, Kobos D, Dajani AS. Efficacy and safety of ceforanide in the treatment of childhood infections. Pediatr Infect Dis. 1983 Abstract
  5. Ripa S, La Rosa F, Ghezzi A, Prenna M, Pfeffer M. Pharmacokinetics of ceforanide. Antimicrob Agents Chemother. 1982 Abstract
  6. Estey EH, Weaver SS, LeBlanc BM, Brown N, Ho DH, Bodey GP. Ceforanide kinetics. Clin Pharmacol Ther. 1981 Abstract
  7. Pfeffer M, Gaver RC, Van Harken DR. Human pharmacokinetics of a new braod-spectrum parenteral cephalosporin antibiotic, ceforanide. J Pharm Sci. 1980 Abstract

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