Last update May 24, 2025

Ceforanide

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Second-generation cephalosporin antibiotic for injection or parenteral administration.

At latest update no published data on excretion into breast milk were found.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view  (Rowe 2013, Fulton 1992) without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period (Thirumoorthi 1983), so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Product with very few bibliographic references and marketed in few countries.

Pending further published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Alternatives

  • Cefadroxil (Safe product and/or breastfeeding is the best option.)
  • Ceftibuten (Safe product and/or breastfeeding is the best option.)
  • Ceftriaxone Sodium (Safe product and/or breastfeeding is the best option.)
  • Cephalexin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ceforanide in other languages or writings:

Group

Ceforanide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ceforanide in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 520 daltons
Protein Binding 81 %
VD 0.17 l/Kg
pKa 8.93 -
T½ 2.6 - 3 hours

References

  1. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  4. Thirumoorthi MC, Buckley JA, Vincent CV, Kobos D, Dajani AS. Efficacy and safety of ceforanide in the treatment of childhood infections. Pediatr Infect Dis. 1983 Abstract
  5. Ripa S, La Rosa F, Ghezzi A, Prenna M, Pfeffer M. Pharmacokinetics of ceforanide. Antimicrob Agents Chemother. 1982 Abstract
  6. Estey EH, Weaver SS, LeBlanc BM, Brown N, Ho DH, Bodey GP. Ceforanide kinetics. Clin Pharmacol Ther. 1981 Abstract
  7. Pfeffer M, Gaver RC, Van Harken DR. Human pharmacokinetics of a new braod-spectrum parenteral cephalosporin antibiotic, ceforanide. J Pharm Sci. 1980 Abstract

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