Last update Oct. 15, 2016

Cefmetazole

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Second-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Cho 1981, No authors listed 1981).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefmetazole since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

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Cefmetazole in other languages or writings:

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Tradenames

Main tradenames from several countries containing Cefmetazole in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 472 daltons
Protein Binding 65 - 85 %
Tmax (im) 0.7 - 1.2 hours
T½ 1.1 - 1.5 hours

References

  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Tan JS, Salstrom SJ, Signs SA, Hoffman HE, File TM. Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels. Antimicrob Agents Chemother. 1989 Abstract
  3. Rodriguez-Barbero J, Mariño EL, Dominguez-Gil A. Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults. Antimicrob Agents Chemother. 1985 Abstract
  4. Cho N, Fukunaga K, Kunii K. [A study of clinical application of cefmetazole in perinatal period (author's transl)]. Jpn J Antibiot. 1981 Abstract
  5. [No authors listed] [A study of safety of cefmetazole (CS-1170) in pregnant women during the perinatal stage (author's transl)]. Jpn J Antibiot. 1981 Abstract

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