Last update May 24, 2025

سافميتازول

Compatible

Safe product and/or breastfeeding is the best option.

Second-generation cephalosporin antibiotic for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant. (Cho 1981, No authors listed 1981)

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal microbiome in infants whose mothers take antibiotics should be taken into account. (Ito 1993)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

سافميتازول is Cefmetazole Sodium in Arabic.

Is written in other languages:

Group

سافميتازول belongs to this group or family:

Tradenames

Main tradenames from several countries containing سافميتازول in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 494 daltons
Protein Binding 65 - 85 %
Tmax (im) 0.7 - 1.2 hours
T½ 1.5 ± 0.14 hours

References

  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Tan JS, Salstrom SJ, Signs SA, Hoffman HE, File TM. Pharmacokinetics of intravenous cefmetazole with emphasis on comparison between predicted theoretical levels in tissue and actual skin window fluid levels. Antimicrob Agents Chemother. 1989 Abstract
  3. Rodriguez-Barbero J, Mariño EL, Dominguez-Gil A. Pharmacokinetics of cefmetazole administered intramuscularly and intravenously to healthy adults. Antimicrob Agents Chemother. 1985 Abstract
  4. Cho N, Fukunaga K, Kunii K. [A study of clinical application of cefmetazole in perinatal period (author's transl)]. Jpn J Antibiot. 1981 Abstract
  5. [No authors listed] [A study of safety of cefmetazole (CS-1170) in pregnant women during the perinatal stage (author's transl)]. Jpn J Antibiot. 1981 Abstract

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