Last update Dec. 4, 2020

Carboprost

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Carboprost is a synthetic prostaglandin similar to prostaglandin F2 alpha (dinoprostone). It induces the contractility of the uterine smooth muscles. It is administered intramuscularly in postpartum hemorrhages due to uterine atony when other drugs have not been effective.

Since the last update we have not found published data on its excretion in breastmilk.

Its very rapid elimination and its very low concentration in plasma (high intramuscular doses only produce concentrations of picograms in plasma: Pfizer 2014) make it very unlikely that significant quantities will transfer into breastmilk.

It has been widely used in obstetrics without encountering problems in breastfeeding babies.
Several experts consider its use during breastfeeding to be probably compatible. (Hale 2019, Briggs 2017).

Alternatives

We do not have alternatives for Carboprost.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Carboprost is also known as Carboprost Trometamol. Here it is a list of alternative known names::


Carboprost in other languages or writings:

Group

Carboprost belongs to this group or family:

Tradenames

Main tradenames from several countries containing Carboprost in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 490 daltons
pKa 4.36 -
Tmax 0.3 - 0.5 hours
0.13 hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Pfizer. Carboprost Drug Summary. 2014 Full text (in our servers)

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