Last update Dec. 4, 2020

Carboprost Trometamol

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Carboprost is a synthetic prostaglandin similar to prostaglandin F2 alpha (dinoprostone). It induces the contractility of the uterine smooth muscles. It is administered intramuscularly in postpartum hemorrhages due to uterine atony when other drugs have not been effective.

Since the last update we have not found published data on its excretion in breastmilk.

Its very rapid elimination and its very low concentration in plasma (high intramuscular doses only produce concentrations of picograms in plasma: Pfizer 2014) make it very unlikely that significant quantities will transfer into breastmilk.

It has been widely used in obstetrics without encountering problems in breastfeeding babies.
Several experts consider its use during breastfeeding to be probably compatible. (Hale 2019, Briggs 2017).


We do not have alternatives for Carboprost Trometamol.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Carboprost Trometamol is also known as

Carboprost Trometamol in other languages or writings:


Carboprost Trometamol belongs to this group or family:


Main tradenames from several countries containing Carboprost Trometamol in its composition:


Variable Value Unit
Molecular weight 490 daltons
pKa 4.36 -
Tmax 0.3 - 0.5 hours
0.13 hours


  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from Consulted on March 17, 2022 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Pfizer. Carboprost Drug Summary. 2014 Full text (in our servers)

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