Last update Jan. 16, 2021

Calcium (±)-2-(3-phenoxyphenyl)propionate dihydrate


Safe substance and/or breastfeeding is the best option.

Fenoprofen is a nonsteroidal, anti-inflammatory , propionic acid derivative with analgesic, antiinflammatory and antipyretic properties.
It is indicated for relief of mild to moderate pain in adults and for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
Oral administration every 4 to 8 hours.

According to the manufacturer It is excreted in breast milk in clinically insignificant amounts; the drug levels in breast milk were usually below the levels of accurate assessment (Xspire Pharma 2016, Rubin 1974).

Until there is further published data on this drug in relation to breastfeeding, known safer alternatives may be preferable, especially during the neonatal period and in cases of prematurity.


  • Ibuprofen (Safe substance and/or breastfeeding is the best option.)
  • Paracetamol (Safe substance and/or breastfeeding is the best option.)
  • Piroxicam (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Calcium (±)-2-(3-phenoxyphenyl)propionate dihydrate is Fenoprofen Calcium in Chemical name.

Is written in other languages:


Calcium (±)-2-(3-phenoxyphenyl)propionate dihydrate belongs to this group or family:


Main tradenames from several countries containing Calcium (±)-2-(3-phenoxyphenyl)propionate dihydrate in its composition:


Variable Value Unit
Oral Bioavail. 80 %
Molecular weight 559 daltons
Protein Binding 99 %
VD 0.1 l/Kg
pKa 3.96 -
Tmax 1 - 2 hours
2.5 hours
M/P ratio 0.017 -


  1. Xspire Pharma. Fenoprofen. Drug Summary. 2016 Full text (in our servers)
  2. Rubin A, Chernish SM, Crabtree R, Gruber CM, Helleberg L, Rodda BE, Warrick P, Wolen RL, Ridolfo AS. A profile of the physiological disposition and gastro-intestinal effects of fenoprofen in man. Curr Med Res Opin. 1974;2(9):529-44. No abstract available. Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM