C₆H₇N₃O

It is an antibiotic derived from hydrazide used in the treatment of tuberculosis. Daily oral administration or three times a week.

It is excreted in breast milk in moderate amounts (DR 10 to 16%), which is much lower than the dose commonly used in newborns and infants. ^{(Zuma 2022, Garessus 2019, Singh 2008, Snider 1984, Ricci 1954, Lass 1953)}

No significant problems have been observed in infants whose mothers took it ^{(Keskin 2008, Drobac 2005)}. One infant, whose mother was treated with anti-tuberculosis drugs during pregnancy and 7 months of breastfeeding, had moderately high levels of liver transaminases with normal clinical and developmental status ^{(Peters 2008)}. Low plasma levels of 6-beta-hydroxycortisol have been found in 10 infants of mothers treated with INH. ^{(Toddywalla 1995)}

Low levels of INH have been detected in the plasma ^{(Garessus 2019)} and urine ^{(Ricci 1954)} of infants whose mothers were taking INH.

Various medical societies and expert consensus groups consider the use of this medication during breastfeeding to be safe. ^{(Algharably 2023, Nahid (CDC) 2016, Malhamé 2016, Baquero-Artigao 2015, Mittal 2014, Singh 2008, WHO 2007, Schram 2005, Blumberg 2003, Dautzenberg 1988, Tran 1998)}

American Academy of Paediatrics: medication usually compatible with breastfeeding ^{(AAP 2001)}. WHO 2002 list of essential medicines: compatible with breastfeeding. ^{(WHO 2002)}

To avoid the risk of neuropathy, vitamin B₆ (pyridoxine) should be added to the treatment of the mother and infant, especially in cases of malnutrition, diabetes or other diseases, or new pregnancy ^{(Di Comite 2016, Principi 2016, Baquero-Artigao 2015, Steichen 2006, Blumberg 2003, CDC 2003)}. Vitamin B₃ (niacin) should also be added to prevent the risk of pellagra. ^{(Nabity 2022)}

See below the information of this related product:

• Maternal Tuberculosis (TBC) (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)