Last update Sept. 7, 2025

C22H19NO4

Compatible

Safe product and/or breastfeeding is the best option.

Intestinal stimulant laxative used in the treatment of constipation and for bowel evacuation prior to investigative procedures or surgery. Oral or rectal administration.

Its very low oral bioavailability due to minimal intestinal absorption results in very low plasma levels, which explains the absence of transfer to breast milk (undetectable levels). (Friedrich 2011)

Expert authors consider the use of this medication during breastfeeding to be acceptable. (Hale, LactMed, Gharehbaghi 2016)

On prevention or treating constipation, it is essential a balanced and rich-in-fiber diet along with a lot of fluids and physical exercise.

Alternatives

We do not have alternatives for C22H19NO4 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

C22H19NO4 is Bisacodyl in Molecular formula.

Is written in other languages:

Group

C22H19NO4 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C22H19NO4 in its composition:

List of 35 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 5 - 16 %
Molecular weight 361 daltons
VD 2.6 l/Kg
Tmax 3 - 4 hours
T½ 7.3 hours
Theoretical Dose 0 mg/Kg/d
Relative Dose 0 %
Ped.Relat.Dose 0 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Gharehbaghi K, Gharehbaghi DR, Wierrani F, Sliutz G. [Treatment of Chronic Functional Constipation during Pregnancy and Lactation]. Z Geburtshilfe Neonatol. 2016 Abstract
  4. Müller-Lissner S. Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments. Expert Opin Drug Metab Toxicol. 2013 Abstract
  5. AEMPS. Bisacodilo. Ficha técnica. 2012 Full text (in our servers)
  6. Friedrich C, Richter E, Trommeshauser D, de Kruif S, van Iersel T, Mandel K, Gessner U. Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women. Drug Metab Pharmacokinet. 2011 Abstract Full text (link to original source) Full text (in our servers)

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