Last update Nov. 8, 2024

C21H21ClN2O8

Compatible

Safe product and/or breastfeeding is the best option.

It is a derivative of tetracycline with uses similar to those of tetracycline but with more prolonged action.  It is administered orally in 2 to 4 daily doses.

It is excreted in breast milk in clinically insignificant amounts. (von Kobyletzki 1962)

Oral bioavailability is very low because it forms inabsorbable chelates with milk calcium, which makes it difficult for it to pass into infant plasma from ingested breast milk. (Chin 2001)

Alternatives

  • Tetracycline (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

C21H21ClN2O8 is Demeclocycline in Molecular formula.

Is written in other languages:

C21H21ClN2O8 is also known as

Groups

C21H21ClN2O8 belongs to these groups or families:

Tradenames

Main tradenames from several countries containing C21H21ClN2O8 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 - 80 %
Molecular weight 465 daltons
Protein Binding 70 %
pKa 2.94 -
Tmax 3 - 4 hours
T½ 12 (10 - 17) hours
M/P ratio 0.7 -
Theoretical Dose 0.0075 - 0.21 mg/Kg/d
Relative Dose 0.075 - 4.2 %

References

  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  2. von KOBYLETZKI, STRAUCH D. [Demethylchloreteracycline in the umbilical vein blood and the amniotic fluid]. Z Geburtshilfe Gynakol. 1962 Sep;159:246-51. German. No abstract available. Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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