Last update July 24, 2014

Demeclocycline

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Although it is secreted into breast milk it has not been detected in infant’s blood because it forms unabsorbable chelate compounds with milk calcium. It is not recommended a long-term use (more than 3-4 weeks) since damage on bone growth plates, teeth discoloration, or alteration of intestinal flora may occur.

Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics.

Withdrawn from the market in Spain.

Alternatives

  • Tetracycline (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Demeclocycline is also known as


Group

Demeclocycline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Demeclocycline in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 66 %
Molecular weight 501 daltons
Protein Binding 70 %
Tmax 4 hours
T½ 12 hours
M/P ratio 0.7 -
Theoretical Dose 0.15 mg/Kg/d
Relative Dose 1.5 %

References

  1. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract

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