Last update Sept. 4, 2022

C19H24N2O,HCl

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a serotonin (5-HT3) antagonist used for the prevention and treatment of nausea and vomiting caused by chemotherapy and surgery. Oral (alone or associated with netupitant) or intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its pharmacokinetic data do not allow a good prediction of its possible excretion in breast milk, since while its low protein binding and low molecular weight, its very large volume of distribution would make it difficult.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Metoclopramide (Safe product and/or breastfeeding is the best option.)
  • Ondansetron (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C19H24N2O,HCl is Palonosetron Hydrochloride in Molecular formula.

Is written in other languages:

Groups

C19H24N2O,HCl belongs to these groups or families:

Tradenames

Main tradenames from several countries containing C19H24N2O,HCl in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 97 %
Molecular weight 333 daltons
Protein Binding 62 %
VD 8.3 ± 2.5 l/Kg
40 - 100 hours

References

  1. EMA. Akynzeo. Ficha técnica. 2020 Full text (in our servers)
  2. AEMPS. Palonosetrón. Ficha técnica. 2019 Full text (in our servers)
  3. Purdue. Palonosetron. Drug Summary. 2017 Full text (in our servers)
  4. Purdue. Akynzeo. Drug Summary. 2017 Full text (in our servers)

Total visits

619

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM