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Aprepitant is a neurokinin-1 receptor antagonist. It is used for the prevention and treatment of nausea and vomiting caused by chemotherapy and surgery. Oral administration in combination with palonosetron.
On latest update relevant data on breastfeeding was not found.
Its very high volume of distribution, and its very high plasma protein binding make excretion into breast milk unlikely.
Side effects are few and usually mild.
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.