Last update Aug. 17, 2019

Buclizine Hydrochloride

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

First generation antihistamine, derived from piperazine with moderate sedative and anticholinergic effects. Antivertigo, antipruritic and antiemetic properties (MK 2019, Mostafa 2011).
Used in the treatment and prevention of travel sickness, and to treat vertigo and migraines (associated with several other drugs) and as an appetite stimulant without documented evidence of its effectiveness (Babu 2011).
Oral administration once a day. Occasional use during travel.

Since the last update we have not found published data on its excretion in breastmilk.

There are very few bibiographical references which are also very old, and it is sold in few countries.

The lack of pharmacokinetic data makes it difficult to accurately predict its possible excretion in breastmilk.

First-generation antihistamines, at high doses, inhibit prolactin secretion (Messinis 1985, Board 1981, Golstein 1979, Wortsman 1979), but the stimulation of infant suction is usually sufficient to ensure breastmilk production (Messinis 1985 ).
No decreases in breastmilk production have been recorded with usual doses of antihistamines.

The occasional use or minimal doses of antihistamines, even first generation, is considered safe during breastfeeding (So 2010), with low frequency of side effects, which are also mild (Ito 1993), so the occasional use of buclizine to avoid travel sickness can be considered compatible with breastfeeding.

Buclizine preparations associated with various medications during breastfeeding are not recommended and there is no evidence that it is effective in treating vertigo or migraines or other conditions.

Monitor drowsiness and the adequate feeding of the infant if this medicine is used during breastfeeding.
It is not recommended to share a bed with the baby if this medication is taken due to an increased risk of suffocation or sudden infant death (UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006).


  • Dimenhydrinate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Diphenhydramine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Hydroxyzine (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Loratadine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Buclizine Hydrochloride is also known as

Buclizine Hydrochloride in other languages or writings:


Buclizine Hydrochloride belongs to this group or family:


Main tradenames from several countries containing Buclizine Hydrochloride in its composition:


Variable Value Unit
Molecular weight 506 daltons
pKa 8.04 -
Tmax 2 - 3 hours
8 - 15 hours


  1. MK. Buclizina (Vibazina). Ficha técnica. 2019 Full text (link to original source) Full text (in our servers)
  2. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  3. UNICEF. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  4. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  5. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. None 2013 Full text (link to original source) Full text (in our servers)
  6. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  7. Babu TA. Buclizine is back again! This time as a pediatric appetite stimulant. Indian J Pharmacol. 2011 Apr;43(2):219. Abstract
  8. Mostafa GA, Al-Badr AA. Buclizine. Profiles Drug Subst Excip Relat Methodol. 2011;36:1-33. Abstract
  9. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010 May;56(5):427-9. Abstract Full text (link to original source) Full text (in our servers)
  10. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  11. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  12. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  13. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  14. Messinis IE, Souvatzoglou A, Fais N, Lolis D. Histamine H1 receptor participation in the control of prolactin secretion in postpartum. J Endocrinol Invest. 1985 Apr;8(2):143-6. Abstract
  15. Board JA, Fierro RJ. Effect of cyproheptadine on chlorpromazine stimulation of prolactin in women. Am J Obstet Gynecol. 1981 Jan 15;139(2):160-3. Abstract
  16. Wortsman J, Soler NG, Hirschowitz J. Cyproheptadine in the management of the galactorrhea-amenorrhea syndrome. Ann Intern Med. 1979 Jun;90(6):923-5. Abstract
  17. Golstein J, Vanhaelst L, Bruno OD, L'Hermite M. Effect of cyproheptadine on thyrotrophin and prolactin secretion in normal man. Acta Endocrinol (Copenh). 1979 Oct;92(2):205-13. Abstract

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