Last update Jan. 10, 2023
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Brinzolamide in other languages or writings:
Brinzolamide belongs to this group or family:
Main tradenames from several countries containing Brinzolamide in its composition:
Variable | Value | Unit |
---|---|---|
Molecular weight | 384 | daltons |
Protein Binding | 63 | % |
Tmax | 2 | hours |
T½ | 4.032 | hours |
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e-lactancia is a resource recommended by IHAN of Spain
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It is a carbonic anhydrase inhibitor (CAI) with actions similar to those of acetazolamide. It is used as 1% drops for topical treatment to lower intraocular pressure or glaucoma, either alone or in conjunction with a topical beta-blocker or prostaglandin analogue.
At the date of the last update we did not find any published data on its excretion in breast milk.
Concentrations of brinzolamide and its metabolite N-desethyl-brinzolamide are low and generally below detection limits (FDA 2015, EMA 2010). For this reason and because it is usually used as a topical treatment its presence in mother’s milk is unlikely. Like most ophthalmologic compounds for topical use, a low dose and poor absorption make it compatible with breastfeeding.
Systemic absorption should be minimized by pressing the tear duct (inner corner of the eye) with the finger for 1 to 2 minutes and administering the dose immediately after breastfeeding. (Belkin 2020, Blumen 2020, Méndez 2012)
Several medical societies and expert authors consider the use of CAI to be safe during breastfeeding. (Blumen 2020)