Last update March 29, 2016

Benzydamine Hydrochloride

Compatible

Safe substance and/or breastfeeding is the best option.

Nonsteroidal antiinflammatory agent that is locally used on skin and in solution for oral application or vaginal douche.

At latest update no published data on excretion into breast milk were found.

Because the small dose used and low absorption of most topical dermatological preparations with limited absorption to plasma, it is unlikely the passage of significant amounts to breast milk. This is true whenever there is not abuse of it since cases of renal impairment after prolonged and excessive administration have been reported.

If used, do not apply on the chest, large areas and for prolonged periods of time to prevent a systemic absorption.

Alternatives

We do not have alternatives for Benzydamine Hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Benzydamine Hydrochloride in other languages or writings:

Group

Benzydamine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Benzydamine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 5 %
Molecular weight 346 daltons
Protein Binding 20 %
VD 3 l/Kg
T½ 13 hours

References

  1. MHRA. Benzydamine. Drug Summary. 2015 Full text (in our servers)
  2. AEMPS. Beincidamina. Ficha técnica. 1999 Full text (in our servers)
  3. O'Callaghan CA, Andrews PA, Ogg CS. Renal disease and use of topical non-steroidal anti-inflammatory drugs. BMJ. 1994 Abstract Full text (link to original source) Full text (in our servers)
  4. Baldock GA, Brodie RR, Chasseaud LF, Taylor T, Walmsley LM, Catanese B. Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects. Biopharm Drug Dispos. 1991 Abstract
  5. Chasseaud LF, Catanese B. Pharmacokinetics of benzydamine. Int J Tissue React. 1985 Abstract
  6. Catanese B, Facchini V, Barillari G, Putzolu S. Serum levels of benzydamine following the topical use of this drug in gynecology. Clin Exp Obstet Gynecol. 1980 Abstract

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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