Last update Aug. 18, 2020

Bambuterol Hydrochloride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a long acting bronchodilator that is metabolized to terbutaline.
It is indicated in the treatment of bronchial asthma.
Oral administration once a day.

Since the last update we have not found any published data on its excretion in breast milk.

Its low oral bioavailability (Lailan 2018, Astra 2017) hinders transfer to infant plasma from breastmilk, except in premature infants and the immediate neonatal period when there may be increased intestinal permeability.

Inhaled preparations of bronchodilators are preferable because of their negligible plasma absorption and subsequent nil excretion in breast milk.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Bambuterol Hydrochloride in other languages or writings:

Group

Bambuterol Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Bambuterol Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 10 - 20 %
Molecular weight 404 daltons
Protein Binding 40 - 50 %
Tmax 2 - 6 hours
13 - 21 hours

References

  1. Lailan. Bambuterol (Bambec). Ficha técnica. 2018 Full text (in our servers)
  2. Astra Z. Bambuterol (Bambec). Drug Summary. 2017 Full text (in our servers)
  3. Nyberg L, Rosenborg J, Weibull E, Jönsson S, Kennedy BM, Nilsson M. Pharmacokinetics of bambuterol in healthy subjects. Br J Clin Pharmacol. 1998 May;45(5):471-8. Abstract

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